Image:Tammy Abraham and Timo Werner were both on the scoresheet – Advertisement – 3:09 Ashley Cole and Graeme Souness debate whether Chelsea can compete with Manchester City and Liverpool for the Premier League title this season. 2:09 Hakim Ziyech turned in a man of the match display and provided two assists on Saturday – Advertisement – FREE TO WATCH: Highlights from Chelsea’s win over Sheffield United in the Premier League. Lampard’s side have scored 14 in four games, and conceded just one in six, but the manager insists Chelsea need to prove their strength over longer than a month. 2:44 Frank Lampard insists Chelsea’s 4-1 victory over Sheffield United was their best performance of the season, but is keeping his feet firmly on the ground.Hakim Ziyech starred, creating two goals as Chelsea fought back from a goal down to register a fourth straight victory, taking them to within a point of Liverpool at the top of the Premier League.- Advertisement – – Advertisement – “That’s the best performance of the season in complete terms,” he said in his post-match press conference, having said on Sky Sports: “We’re third, and that might change by the end of the weekend but at the same time, given the start we had where players were injured and we were starting to put it together, the lack of pre-season, now we’re seeing some of the work.“The season is long and it’s very early days so I’m keeping my feet on the ground. We have challenge after challenge coming up, the players now go away for two weeks before we face Newcastle. Every game will be challenging.“The balance of the team was good today, but we must continue. I know how football is, and I know that it’s not just about individuals. It was always going to be hard work against Sheffield United but they came through it.”Lampard has continually stressed that his side are a work in progress, but the front line in particular seem to be clicking in recent weeks. Ashley Cole on Sky Sports:“I think they’ve got the players to challenge. We can sit here and say they can challenge, but football is fickle. It can swing so quickly as you can have one good performance like they had today against a Sheffield United team who I feel shouldn’t be bottom. Their quality is much higher than they’re showing positionally.“After they come back from the international break, they’ve got Newcastle and if they lose that there will again be criticism. So we have to be careful, but right now with the changes they’ve made and the defenders that have come in, I do feel like they can challenge for the title.”Graeme Souness on Sky Sports:“I definitely think they’ll get in the top four but I feel they’ll still be short [of challenging for the title] behind Man City and Liverpool. You look at the areas that they’re not so strong in and they’re hoping that Thiago Silva and Edouard Mendy are going to be the difference. But let’s see by early new year if they’re going to make such a difference against the bigger guys. Sheffield United boss Chris Wilder said Chelsea are one of the top three sides in the country alongside Manchester City and Liverpool, and though Lampard insists the signs are good, he’s tempering expectations.“People expected our attacking players to click on day one of the season, but of course that doesn’t happen. It’s a work in progress, and the movement and the relationships on the pitch is something you have to work on.“There are great signs, but we need to keep going.”Chelsea’s fixturesSat Nov 21: Newcastle (a)Tues Nov 24: Rennes (a)Sat Nov 28: Tottenham (h)Wed Dec 2: Sevilla (a)Sat Dec 5: Leeds (h)Tues Dec 8: FK Krasnodar (h)Sat Dec 12: Everton (a)Can Chelsea challenge for the title? “Timo Werner’s first year in English football will prove very demanding and I just look at the strength that Liverpool and City have. Sergio Aguero is an enormous miss to City when he’s not playing, but the rest of the team is fabulous.“Even with Liverpool losing Virgil van Dijk, and the bad run they’ve had of injuries to players who came in, I still think they’re a bit ahead of Chelsea right now.“I’m thinking in a year’s time, Chelsea might be looking for another couple of centre-backs, and I still have that nagging doubt about the centre of defence. I’d like to reserve my judgment on this area of the pitch for Chelsea as the goalkeeper’s come in and only played a handful of games.”What’s next?Chelsea return to action after the international break with a trip to Newcastle United on Saturday November 21 at 12.30pm, while Sheffield United host West Ham on Sunday November 22, live on Sky Sports Premier League at 2pm.
May 15, 2008 (CIDRAP News) – Certain mutations that make the H5N1 influenza virus resistant to the antiviral drug oseltamivir (Tamiflu) leave it susceptible to zanamivir (Relenza), a finding that suggests nations should not rely on oseltamivir alone in preparing for a flu pandemic, according to a report published by British scientists this week.Writing in the journal Nature, the scientists describe the properties and molecular structures of the neuraminidase proteins from two H5N1 variants that have been found in some humans who were treated with oseltamivir. Their findings show that these mutant forms are resistant to oseltamivir but still susceptible to zanamivir and have structural peculiarities that explain this difference.In combination with other recent findings about oseltamivir-resistant forms of H5N1 and the seasonal flu virus H1N1, “our results indicate that it would be prudent for pandemic stockpiles of oseltamivir to be augmented by additional antiviral drugs, including zanamivir,” says the report by Patrick J. Collins, of the National Institute for Medical Research in London, and colleagues.Oseltamivir makes up 80% to 85% of the US stockpile of antiviral drugs for flu, with zanamivir constituting the rest, according to a recent report by the congressionally chartered Institute of Medicine. The report recommended increasing the stockpile, which contained about 71 million treatment courses as of last month.Neuraminidase, which corresponds to the “N” in virus labels such as H5N1, is a viral surface protein that gives new copies of the virus within infected cells the ability to slip through the cell membrane and find other cells to infect. The British scientists studied the neuraminidase found in wild-type H5N1 viruses and N1 forms of neuraminidase that contained three different mutations:His274Tyr, which has been linked to oseltamivir resistance in some fatal human H5N1 cases and was also found in a number of H1N1 viruses from seasonal flu cases this past winterAsn294Ser, which has been found in more than one subtype of flu virus from patients treated with oseltamivirTyr252His, which has been found in one clade of H5N1 virus and has not been linked with drug treatmentThe researchers analyzed the ability of both antivirals to bind to and inhibit these neuraminidases. They found that, compared with the wild-type neuraminidase, the His274Tyr and Asn294Ser variants showed strong resistance to oseltamivir, while the Tyr252His form was actually more susceptible to the drug. None of the mutant forms showed much increase in resistance to zanamivir.The scientists used x-ray crystallography to examine the structure of the neuraminidases in the hope of finding a physical explanation for the oseltamivir resistance. They detected and diagrammed specific structural characteristics of the oseltamivir-neuraminidase and zanamivir-neuraminidase complexes that appear to account for the differences in resistance.The structural basis for the differences has to do with “an altered hydrophobic pocket in the active site of the enzyme required for oseltamivir binding,” the report says.The researchers note that the His274Tyr mutant was found recently in many oseltamivir-resistant H1N1 viruses isolated from flu patients in Europe, even though the patients had no known exposure to the drug. Like the neuraminidase variants used in the study, the H1N1 isolates remained susceptible to zanamivir.”Evidently, if the His274Tyr mutation also becomes common in avian H5N1, the effectiveness of oseltamivir would be limited and the value of stockpiles compromised,” the scientists write. “Considered together with the success of HAART (highly active antiretroviral therapy) against HIV, it would be prudent to reassess the suitability of single-drug, pre-pandemic stockpiles and to develop effective drug combination treatments.”Bill Hall, a spokesman for the US Department of Health and Human Services (HHS) in Washington, DC, called the Nature report interesting but said it would not prompt a change in the agency’s antiviral stockpiling strategy.”We have known about selected instances of resistance to oseltamivir for some time, but so far, the number of reported instances of such resistance has been extremely limited,” Hall told CIDRAP News by e-mail. “The instances of Tamiflu-resistant viruses are not correlated strongly with intensity of Tamiflu use in a given population or environment. It’s also important to remember that any Tamiflu resistance that may exist in currently circulating viruses is in no way predictive of potential resistance in a yet-to-emerge virus with pandemic potential.”So, this article is interesting from a scientific perspective, but given the limited instances in which resistance has been documented, our public health approach to our stockpiling strategy remains unchanged.”Collins PJ, Haire LF, Lin YP, et al. Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants. Nature 2008 (online publication May 14) [Abstract]http://www.nature.com/nature/journal/vaop/ncurrent/full/nature06956.htmlSee also: Apr 25 CIDRAP News story “IOM: US likely to need bigger antiviral stockpile”Mar 19 CIDRAP News story “Researchers warn of resistant flu, foodborne microbes”Jan 29 CIDRAP News story “Europeans find Tamiflu resistance in seasonal flu virus”
Jack Dorsey on Tuesday said that both companies he heads — Twitter and Square — are making “Juneteenth” a holiday for employees in commemoration of the end of slavery in the US.The holiday set for each June 19 marks the day in 1865 when Union soldiers landed in Texas with the message that the Civil War was over and slavery ended, according to a Juneteenth.com website linked to by Dorsey.President Abraham Lincoln more than two years earlier had issued the Emancipation Proclamation, which went into effect at the start of 1863. Topics : The arrival of Union troops in Texas provided needed strength to overcome resistance there to freeing slaves, according to Juneteenth.com.”Both Twitter and Square are making #Juneteenth [June 19th] a company holiday in the US, forevermore,” Dorsey said in a tweet.”A day for celebration, education, and connection.”He added in a follow-up tweet that Twitter and Square will work to make company holidays of days celebrating emancipation in other countries where it operates.
Unai Emery has defended playing only one striker against Watford (Getty Images)Pierre-Emerick Aubameyang has appeared to question Unai Emery’s tactics following Arsenal’s 1-0 win over Watford on Monday evening.Aubameyang capitalised on an error from Ben Foster to score the only goal of the game at Vicarage Road and fire the Gunners back into fourth position in the Premier League.But the Gabon striker has suggested that he was unhappy with Emery’s decision to leave Alexandre Lacazette on the bench for the entire game.‘Everybody knows that I like to play with Laca because we have a great partnership,’ Aubameyang told Sky Sports.ADVERTISEMENT‘Sometimes one plays, the other is on the bench. It’s like that. You have to fight for the team.AdvertisementAdvertisement‘I think you know that I like to play with two strikers but I don’t want to say it because the coach will be maybe a bit angry.’ Pierre-Emerick Aubameyang scored Arsenal’s winner against Watford (Getty Images)Emery, meanwhile, has explained that he played Aubameyang as the sole striker in order to gain more control in Arsenal’s midfield.‘First I decided to do the change of Lucas Torreira because after the red card, the atmosphere is against him and also the doctor said to me in the first half that he has a little pain for Thursday and I decided okay, it’s the moment [to substitute him],’ said the Arsenal manager.‘We played with the same system – 4-2-3-1 – with Xhaka and Aaron coming closer to Xhaka for the build-up and Mesut behind Auba as a midfielder. Metro Sport ReporterTuesday 16 Apr 2019 4:25 pmShare this article via facebookShare this article via twitterShare this article via messengerShare this with Share this article via emailShare this article via flipboardCopy link24Shares Pierre-Emerick Aubameyang questions Unai Emery after Alexandre Lacazette was left out of Arsenal’s win over Watford Comment Advertisement Alexandre Lacazette was left on the bench as Arsenal beat Watford (Getty Images)More: FootballRio Ferdinand urges Ole Gunnar Solskjaer to drop Manchester United starChelsea defender Fikayo Tomori reveals why he made U-turn over transfer deadline day moveMikel Arteta rates Thomas Partey’s chances of making his Arsenal debut vs Man City‘We didn’t control like I wanted to control the match. We are thinking and I was thinking to play with three centre backs to be enough for our build-up and use one player more in the middle, like Matteo as a possibility to help with Xhaka, help with Aaron and Mesut, to give the security in the midfield.‘But I didn’t do this decision on the pitch with all the control I wanted, so after I changed and recovered a 4-2-3-1 with Ainsley.‘Above all, also in our team, the second half they can take some moments and the possibility to score in set-pieces or a long ball and a second action.‘We worked very well on set-pieces and the long balls with second actions but the most important for us was to score the second goal to control the match.’More: Arsenal FCArsenal flop Denis Suarez delivers verdict on Thomas Partey and Lucas Torreira movesThomas Partey debut? Ian Wright picks his Arsenal starting XI vs Manchester CityArsene Wenger explains why Mikel Arteta is ‘lucky’ to be managing Arsenal Advertisement
Juanico said government hospitals in otherprovinces or cities in the region lacked the facilities to make them capable ofhandling COVID-19 patients with severe symptoms. As of this writing, Region 6 has 16 COVID-19cases spread out in Bacolod City, Iloilo City, Capiz, Iloilo province, andAklan. WVMC has been designated as regional COVID-19dedicated hospital. The doctors also urged the provincialgovernment of Iloilo to strictly enforce “border control” and observe“stringent infection measures” to contain the spread of COVID-19. Medical societies warned that the transfer toWVMC of all COVID-19 cases from various parts of the region could furtherspread the virus causing it. * prohibit COVID-19 patients from beingadmitted in a nonCOVID-19 dedicated hospital whether private or government (andimpose this rule regardless of the patient’s financial status or standing insociety) * use COVID-19 test kits prudently and ensurethat only those who fit the criteria are tested * provide frontliners and healthcare workerswith personal protective equipment The medical societies had argued it would bewiser if other provinces in the region – Antique, Aklan, Capiz, Guimaras,Negros Occidental – identify their respective COVID-19-dedicated healthfacility. A surge in COVID-19 cases could strain thehealthcare system of this city and Iloilo province, they warned. ILOILO City – Not all coronavirus disease 2019(COVID-19) cases in Western Visayas would be lumped at the Western VisayasMedical Center (WVMC) in Mandurriao district, the Department of Health (DOH)assured various medical societies here. But according to Dr. Mary Jane Juanico, focalperson for COVID-19 of DOH Region 6, WVMC’s acceptance of COVID-19 cases fromother provinces would be on a “case to case basis.” According to the World Health Organization(WHO), the most common symptoms of COVID-19 are fever, tiredness, and drycough. Some patients mayhave aches and pains, nasal congestion, runny nose, sore throat or diarrhea. * capacitate provincial hospitals so they willnot have to refer their patients to WVMC According to Juanico, WVMC is the only Level 3hospital in Panay and Guimaras islands which means it has far betterfacilities. So why designate WVMC as regional COVID-19dedicated hospital? The medical societies that expressed concernwere the Iloilo Medical Society, Philippine College of Surgeons Panay Chapter,Philippine Society of General Surgeons Panay Chapter, Philippine College ofPhysicians Western Visayas Chapter, Philippine Society of AnesthesiologistsIloilo Panay Chapter, Philippine Pediatric Society Western Visayas Chapter, andPhilippine Obstetrics and Gynecologic Society. Most people (about 80 percent) recover fromthe disease without needing special treatment, according to WHO. Around one outof every six people who gets COVID-19 becomes seriously ill and developsdifficulty breathing. These symptoms are usually mild and begingradually. Some people become infected but don’t develop any symptoms and don’tfeel unwell. “Not all cases,” Juanico assured the medicalsocieties. They also suggested that all persons underinvestigation – those who show symptoms of COVID-19 but not yet tested or stillwaiting for the results of their test – be considered as positive cases alreadyso that immediate contact tracing could be done and so that these contactscould be isolated. Older people, and those with underlyingmedical problems like high blood pressure, heart problems or diabetes, are morelikely to develop serious illness./PN The Department of Health has designated Western Visayas Medical Center in Iloilo City as the health facility dedicated to coronavirus disease cases. IAN PAUL CORDERO/PN The medical societies urged DOH-6 to:
Milan, Ind. — Margaret Mary Hospital has broken ground on a new medical office in Milan. Dr. Amy Glaser-Carpenter will provide primary care from the new location.Organizations like Holt Properties Inc., Poole Group Inc. and the Napoleon State Bank played a major role in the project. “We are honored to have Margaret Mary Health, an organization with a history of giving to the communities it serves, as our tenant in the new building,” noted Lori Holt of Holt Properties, Inc. “The opportunity to expand the services offered in Milan and contribute to our hometown, a town that we love, just felt like a great thing to do. We want Milan to be a community where people want to live and raise their families, a place to come back to. We are excited to welcome a new doctor to our community.”This will be the third Margaret Mary facility located outside Batesville. “Margaret Mary has been working diligently over the past several years to improve access to care for local families. We realize the most effective way to do this is to bring quality health care providers as close to home as possible. Milan is a great community within our service area and we are excited to open a new practice there,” said Julie Keene, Margaret Mary’s vice president of physician services.
PORT OF SPAIN, Trinidad (CMC) – Former West Indies batsman Bryan Davis, has slammed the preparation of the Trinidad and Tobago Red Force, after the national franchise lost their third game in four outings in the Regional Four-Day Championship on Monday.The 76-year-old, who played four Tests in 1965 against Australia, said the trial games which had been used in the lead-up to last month’s start of the tournament had been inadequate in getting the side ready for the longer format.“I don’t think the team for the last three years has been a well-prepared team,” Davis told the NewsDay here.“I don’t like the whole preparation aspect of the trial matches how it is played, it is too lackadaisical; it does not seem to be following any definite order.“When you reach this level of cricket, this level of cricket is one step away from Test cricket. I think it is preparation. We are not properly prepared for four-day matches.”Red Force started the tournament strongly when they defeated Windward Islands Volcanoes by nine wickets at Queen’s Park Oval here.Their form declined drastically since then, however. They slumped to a 292-run loss to Barbados Pride at the Oval here, drew with Leeward Islands Hurricanes in the third round before suffering back-to-back defeats to Jamaica Scorpions and reigning champions Guyana Jaguars.In their most recent defeat at the Guyana National Stadium in Georgetown on Monday, Davis said he had witnessed a side lacking in motivation.“They have talented players there but I looked at some of the cricket (during the last game) through the computer and men walking around with their shoulders down and they don’t look like if they happy,” said the Trinidadian, who played 112 first class games including two seasons for Welsh county Glamorgan.“They are playing the game but they look like a losing bunch of players. So somehow they are not motivated, and a team is only motivated when they feel they’re good.”Davis believes Red Force’s fortunes may benefit from a change in the captaincy. Currently, Yannick Ottley has charge of the squad but Davis argued the responsibility was too much for the 25-year-old.“I think it is very unfair to put Yannick Ottley as captain of the team because I don’t think he has that experience and I don’t think he has that knowledge,” Davis said.“He might develop it and I hope he does, but certainly he is far too green a cricketer to put into that situation. I think it is tough on him, I am not blaming him, but all this comes back to the selectors.Red Force lie bottom of the six-team standings.
For the UW men’s and women’s swimming and diving teams, this weekend’s Texas Invitational should be the culmination of all the training the two have endured throughout the semester. This will be the event in which the hours upon hours of practice over the last few months will finally pay big dividends, in the form of one or two hundredths of a second. The prestigious event, which will be held at the Lee and Joe Jamail Texas Swimming Center in Austin, Texas, will showcase many of the best swimmers from across the country, and is annually a key stepping-stone for athletes working to qualify for the NCAA Championships in March.”It’s probably our biggest meet,” junior swimmer Hannah McClurg said. “Doing well here gets us set up for the end of the season, Big Ten [Championships] and Nationals, so it’s important that we go in with a lot of motivation and confidence and know what we can do.”Historically, UW has done well at the Texas Invite, with the women’s team placing third at last year’s event (525 points) and the men finishing eighth (117), but this year the competition will be particularly strong. The Badger women go into this weekend’s meet ranked 18th nationally and will face some stiff opposition in the forms of No. 1 Stanford and No. 2 Arizona, but UW assistant coach Eric Fehr is confident the team’s veterans will pick up right where they left off last year.”Our women are a little more experienced [than last year],” Fehr said. “We’re a little more mature team, and we’re hoping to get a lot of people qualified for the NCAA Championships this meet and really compete at a high level.”We want to get a lot of our qualifications for NCAAs to the extent that we can do it here, so we can train through the Big Ten Championships and really focus on NCAAs.” “Relays have always been historically our strongest, and that’s something that we really put a lot of emphasis on, especially with the women’s side,” Fehr added. “That’s going to be the ticket for a lot of the women to get qualified.”As for the men, Fehr hopes to see improvement in all areas. “The men, still a little younger, just want to continue to see some development,” he said. “We’re probably going to be pointing a little more towards the conference to qualify us for NCAA’s. It’s a great test. It’s a chance to swim in a really fast environment with some great competition and see an NCAA-like environment.”Junior swimmer Mike Swanson is also confident that for the Badger men’s team, this weekend won’t be one to forget.”It’s pretty much up for grabs in any event,” Swanson said. “That’s sort of the nature of these midseason, big-time meets. “The meet is set up so that a lot of people get into finals,” he added. “This really sets you up for the championship meet, so everyone is pretty much on their A game.” The men will be going up against a number of top-ranked teams this weekend as well, highlighted by No. 2 Texas and No. 3 Stanford. The men’s best chance of toppling these heavyweights will most likely ride on the success of the men’s relay teams. “Our 800 free relay is pretty important to the guys’ team,” Swanson said. “It’s probably our best shot for making [the NCAA Championships] and doing well [there] so, for the four guys that are going to be on that relay, it’s definitely their biggest event this weekend.”So how has the team managed to deal with the everyday stress of school coupled with the additional pressure of the biggest meet of the fall semester? “Overall, I think we’ve handled it really well,” Swanson said. “We go into this meet forgetting about all that. We try to get everything done, everything set before this meet so that we can just swim. It really is the dress rehearsal to the championship meets.”
For four seasons running, this year’s senior class has lost its last game to Mercyhurst.And although seniors Jenesica Drinkwater, Margot Scharfe and Brittney Krebs won’t get another shot at redemption against the Lakers, the future looks extremely bright for Syracuse (20-14-3, 9-8-3 College Hockey America).Seven of the top nine point scorers for the Orange will be returning, including the top three — sophomores Melissa Piacentini and Nicole Renault and freshman Jessica Sibley. “We have a lot of young, talented players who have already developed so much in one year,” junior Allie LaCombe said in an email. “It’s always exciting to start a new year, but next year looks especially bright.”Sibley, Larissa Martyniuk and Heather Schwarz had the strongest seasons out of the rookies, which Martyniuk credited to the expertise and guidance of this year’s large senior class.AdvertisementThis is placeholder textWhile Sibley registered 26 points on the front line, Martyniuk provided a versatile threat on defense and Schwarz came through with timely playoff scoring.“I feel like the freshmen adapted quite well as the year went on,” Martyniuk said in an email. “We now understand what it’s like to be a student-athlete here.”With the departure of seven seniors, this year’s juniors will be asked to fill a large void both on and off the ice.The Orange graduates the program’s all-time leading goal scorer in Scharfe, along with defender Caitlin Roach, who scored 22 points this year.The leadership responsibilities will now fall on the shoulders of not only LaCombe, but also classmates Akane Hosoyamada, Julie Knerr and Kallie Goodnough. All four will step into more significant roles than they occupied this year.“We have large shoes to fill, but I have faith that our incoming senior class will do an excellent job,” LaCombe said. “We’ll try to lead by example and continue to carry traditions left by the classes before us.”The most impressive wins for SU were a trio of victories against Top-10 opponents. Multi-goal triumphs against Northeastern, Boston College and Robert Morris showed that the Orange had what it took to compete with the likes of Mercyhurst.Syracuse managed a midseason tie against the Lakers and only lost its other four games against them by a combined five goals.Despite the nearness to that elusive first victory over Mercyhurst in program history, Syracuse still fell one round short of last year’s final destination. Its 2013 CHA championship game loss to Mercyhurst was followed up with a semifinal loss in 2014.This, unfortunately, wasn’t enough for SU head coach Paul Flanagan.“Having played in the CHA championship game a year ago, our goal was to get back to that game and win it,” Flanagan said in an email. “We failed to accomplish that, so I feel we underachieved with regard to our expectations.”The Orange fell short of being satisfied, but the returning players give the team reason to expect the same, if not more, of the 2014-15 campaign.Even though the sophomore and junior classes only have four players each, the promise Flanagan has seen in this year’s freshmen and the incoming recruits is cause for optimism.“The future looks bright as we will return a strong nucleus from this year’s team for next season,” Flanagan said. “Hopefully our recruiting efforts from this past year will pay dividends with next year’s freshman class.”As is the case with any team graduating a senior class that has left a significant legacy, the returners will be called on to raise their games.And from its performance this season, Syracuse looks to be in good hands moving forward.Martyniuk said: “Just like with anything, the more you do something the better you get at it. We can only get better.” Comments Facebook Twitter Google+ Published on March 20, 2014 at 12:28 am Contact Matt: firstname.lastname@example.org | @matt_schneidman
Undergraduate Student Government President Monish Tyagi (left) discusses the upcoming event “Explore L.A.” with USG Director of Community Affairs Alex Sellers. Sellers said she expects about 500 students to attend the event this year, held at the Von KleinSmid Center Tuesday from 11 a.m. to 1 p.m., 200 more than did last year.Rachel Bracker | Daily Trojan