America can become its best self. It starts tomorrow.

first_imgOn the other hand, repudiating President Charlottesville and replacing him with a Biden-Harris administration as well as electing a Democratic Senate majority will mark a fundamental shift in the kind of country we will be going forward. We will have a chance—although not a guarantee by any means—to move closer to realizing the ideals of liberty and true equality for every American laid down in the Declaration of Independence. These are the ideals that American activists from a diverse array of backgrounds have long marshaled on behalf of justice.Doing so goes back to Black abolitionist David Walker, who in 1830 called on America: “Hear your languages, proclaimed to the world, July 4th, 1776.” Frederick Douglass in 1852 proclaimed that he drew “encouragement from The Declaration of Independence, the great principles it contains.”- Advertisement – Rev. Dr. Martin Luther King Jr. likewise deployed our founding ideals to lay down a marker in front of hundreds of thousands gathered at the Lincoln Memorial in 1963: “We’ve come to our nation’s capital to cash a check. When the architects of our republic wrote the magnificent words of the Constitution and the Declaration of Independence, they were signing a promissory note to which every American was to fall heir. This note was a promise that all men, yes, black men as well as white men, would be guaranteed the ‘unalienable Rights’ of ‘Life, Liberty and the pursuit of Happiness.’” In perhaps the most famous section of that speech, he proclaimed: “I have a dream that one day this nation will rise up and live out the true meaning of its creed: ‘We hold these truths to be self-evident, that all men are created equal.’”In fighting for LGBTQ equality, Harvey Milk echoed these earlier pioneers when he said: “All men are created equal. Now matter how hard they try, they can never erase those words. That is what America is about.” So did Rep. Barbara Jordan, the first Black woman from the South elected to Congress, who noted, “what the people want is simple. They want an America as good as its promise.” I’ve cited these heroes before, and I’ll keep doing it because they inspire me to fight for the principles they believed in—the principles America must live up to in order to succeed.The impeached president, however, doesn’t care a lick for these principles. He wants to bring us back to a time when we were even further from making them real. He heightens the fears of white Christian Americans about what it would mean if those who are not like them gained an equal share of power. Trump scares his people by pretending these other Americans want some kind of domination over them, when all they seek is merely the measure of full equality promised to all of us.- Advertisement – It comes down a very simple question: Whose America do you want to live in? The America described by Biden, or in Trump’s America, a place where he believes that neo-Nazis who chant “Jews will not replace us” represent “very fine people.”Additionally, as important as the different visions are, the candidates’ differences on policy are equally stark. For starters, Trump will utilize the tax code to send ever more money to the wealthiest, take away health care from tens of millions, make sure millions more are unable to earn a living wage even working full-time, destroy our environment in ways that will be impossible to undo, and block any changes that might be proposed in order to make our law enforcement and justice system treat Americans of every race on equal terms. Oh, and he’ll continue to reject science and needlessly endanger large numbers of Americans during the ongoing pandemic.With Joe Biden, Kamala Harris, and Democratic majorities in Congress, America will have an opportunity to make real progress on all these fronts and more. We’ll be able to enact structural reforms on the Supreme Court and the federal judiciary, on statehood for Washington, D.C., Puerto Rico, Guam, and the U.S. Virgin Islands—which will not only give the American citizens living in those areas the political rights they should have, but also redress at least some of the imbalance in the Electoral College and the Senate that has allowed Republicans to keep coming in second and yet gain the power that is only supposed to accompany victory.In the last four years, we’ve seen some of the worst of what America is. But now, if we do what we must, if we work to get out the vote and fight to ensure that all the votes are counted, we can give America the chance to become what I hope—what I know—it can be. Then there’s Joe Biden. He understands our founding principles, and the struggle throughout our history between those who want America to achieve them and those on the side of white supremacy and other forms of oppression. The latter are the people Biden’s opponent—the second Confederate president—roots for and wants to honor.Just look at the contrast between their remarks around July 4, when we celebrate and, hopefully, reflect on our country’s core ideals. Trump pretends our country is already perfect, and that those fighting for justice today are waging “a merciless campaign to wipe out our history, defame our heroes, erase our values, and indoctrinate our children.” Vice President Biden tells a very different story—one that is honest, reflects reality about our past and present, and projects hope for our future.xOur nation was founded on a simple idea: We’re all created equal. We’ve never lived up to it — but we’ve never stopped trying. This Independence Day, let’s not just celebrate those words, let’s commit to finally fulfill them. Happy #FourthOfJuly! pic.twitter.com/1WrATlx8Xl— Joe Biden (@JoeBiden) July 4, 2020- Advertisement – – Advertisement –last_img read more

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Harry Styles Movie ‘Don’t Worry Darling’ Halted Over COVID-19 Test

first_img– Advertisement – Harry Styles, Florence Pugh and more stars of the upcoming movie Don’t Worry Darling were forced to quarantine after a crew member tested positive for the novel coronavirus.New Line Cinemas confirmed to Deadline that it temporarily shut down production on the Olivia Wilde-directed psychological thriller in downtown Los Angeles on Wednesday, November 4. The website reported that the person who contracted the virus “was in close enough proximity” to the cast, which also includes Chris Pine, Gemma Chan, KiKi Layne and Nick Kroll, so the studio decided that it was necessary to stop filming in case any others were exposed.- Advertisement – Styles joined the cast of Don’t Worry Darling in September after Shia LaBeouf departed due to a scheduling conflict. Filming began on October 20.The movie — which Wilde, 36, also cowrote and stars in — is set in California in the 1950s and follows a housewife named Alice (Pugh) who discovers that her husband, Jack (Styles), is hiding a dark secret. It is the former One Direction member’s second movie role following 2017’s Dunkirk, in which he played a British soldier named Alex. After wrapping Don’t Worry Darling, Styles is set to star alongside Lily James in the LGBTQ drama My Policeman.The “Watermelon Sugar” singer decided to return to acting after the pandemic forced him to postpone his Love on Tour until 2021.- Advertisement – Production is expected to be on hold for approximately 14 days as Styles, 26, Pugh, 24, Pine, 40, and the rest of the cast and crew self-isolate.Don’t Worry Darling is not the first movie to stop filming amid the COVID-19 pandemic. After Tom Hanks tested positive for the virus in March, the Baz Luhrmann-directed Elvis Presley biopic in which the Forrest Gump star, 64, plays the late singer’s longtime manager, Tom Parker, had to press pause on production. Six months later, Robert Pattinson was reportedly diagnosed with the coronavirus, delaying filming for The Batman.- Advertisement – “I’m lucky I’m with friends in our little, safe self-isolation pod,” he told BBC Radio’s 1Xtra Residency in March. “It’s a strange time, but we’re just being careful, listening to music, playing games, doing some face masks. You know, the classic quarantine stuff!”Scroll down to see more photos of the Don’t Worry Darling cast on set before the shutdown.last_img read more

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Frank Lampard: Chelsea win over Sheffield United performance of the season – are the Blues title challengers? | Football News

first_imgTammy Abraham and Timo Werner were both on the scoresheetImage:Tammy Abraham and Timo Werner were both on the scoresheet – Advertisement – 3:09 Ashley Cole and Graeme Souness debate whether Chelsea can compete with Manchester City and Liverpool for the Premier League title this season. 2:09 Hakim Ziyech turned in a man of the match display and provided two assists on Saturday – Advertisement – FREE TO WATCH: Highlights from Chelsea’s win over Sheffield United in the Premier League. Lampard’s side have scored 14 in four games, and conceded just one in six, but the manager insists Chelsea need to prove their strength over longer than a month. 2:44 Frank Lampard insists Chelsea’s 4-1 victory over Sheffield United was their best performance of the season, but is keeping his feet firmly on the ground.Hakim Ziyech starred, creating two goals as Chelsea fought back from a goal down to register a fourth straight victory, taking them to within a point of Liverpool at the top of the Premier League.- Advertisement – – Advertisement – Chelsea vs Sheffield United highlights “That’s the best performance of the season in complete terms,” he said in his post-match press conference, having said on Sky Sports: “We’re third, and that might change by the end of the weekend but at the same time, given the start we had where players were injured and we were starting to put it together, the lack of pre-season, now we’re seeing some of the work.“The season is long and it’s very early days so I’m keeping my feet on the ground. We have challenge after challenge coming up, the players now go away for two weeks before we face Newcastle. Every game will be challenging.“The balance of the team was good today, but we must continue. I know how football is, and I know that it’s not just about individuals. It was always going to be hard work against Sheffield United but they came through it.”Lampard has continually stressed that his side are a work in progress, but the front line in particular seem to be clicking in recent weeks. Ashley Cole on Sky Sports:“I think they’ve got the players to challenge. We can sit here and say they can challenge, but football is fickle. It can swing so quickly as you can have one good performance like they had today against a Sheffield United team who I feel shouldn’t be bottom. Their quality is much higher than they’re showing positionally.“After they come back from the international break, they’ve got Newcastle and if they lose that there will again be criticism. So we have to be careful, but right now with the changes they’ve made and the defenders that have come in, I do feel like they can challenge for the title.”Graeme Souness on Sky Sports:“I definitely think they’ll get in the top four but I feel they’ll still be short [of challenging for the title] behind Man City and Liverpool. You look at the areas that they’re not so strong in and they’re hoping that Thiago Silva and Edouard Mendy are going to be the difference. But let’s see by early new year if they’re going to make such a difference against the bigger guys. Sheffield United boss Chris Wilder said Chelsea are one of the top three sides in the country alongside Manchester City and Liverpool, and though Lampard insists the signs are good, he’s tempering expectations.“People expected our attacking players to click on day one of the season, but of course that doesn’t happen. It’s a work in progress, and the movement and the relationships on the pitch is something you have to work on.“There are great signs, but we need to keep going.”Chelsea’s fixturesSat Nov 21: Newcastle (a)Tues Nov 24: Rennes (a)Sat Nov 28: Tottenham (h)Wed Dec 2: Sevilla (a)Sat Dec 5: Leeds (h)Tues Dec 8: FK Krasnodar (h)Sat Dec 12: Everton (a)Can Chelsea challenge for the title? “Timo Werner’s first year in English football will prove very demanding and I just look at the strength that Liverpool and City have. Sergio Aguero is an enormous miss to City when he’s not playing, but the rest of the team is fabulous.“Even with Liverpool losing Virgil van Dijk, and the bad run they’ve had of injuries to players who came in, I still think they’re a bit ahead of Chelsea right now.“I’m thinking in a year’s time, Chelsea might be looking for another couple of centre-backs, and I still have that nagging doubt about the centre of defence. I’d like to reserve my judgment on this area of the pitch for Chelsea as the goalkeeper’s come in and only played a handful of games.”What’s next?Chelsea return to action after the international break with a trip to Newcastle United on Saturday November 21 at 12.30pm, while Sheffield United host West Ham on Sunday November 22, live on Sky Sports Premier League at 2pm. Timo Werner scored Chelsea's fourthlast_img read more

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Kris Boyd: Table-topping Rangers a different team this season | Football News

first_img2:37 3:01 – Advertisement – Kris Boyd insists table-topping Rangers are a completely different team this season.Steven Gerrard’s side have made a brilliant start to the season, opening up a nine-point gap over Old Firm rivals Celtic – who have two games in hand – at the top of the Scottish Premiership.- Advertisement – preview image Highlights of the Scottish Premiership match between Rangers and Hamilton. They have also had success in Europe, moving to the top of Europa League Group D at the halfway point of the group stage.Ex-Rangers striker Boyd believes his former club are a much-improved side because of the confidence Gerrard has in his squad.“Their performances this season, especially after coming back from Europe, have improved,” Boyd told Sky Sports News.- Advertisement –  Image:Celtic beat Motherwell 4-1 on Sunday Celtic cruised past Motherwell with a 4-1 victory to stay in touch with Rangers heading into the international break, but Boyd insists the champions’ inconsistency will be a huge concern for Neil Lennon.“What will be annoying Neil Lennon is the inconsistency of his team,” Boyd said.“In the past fortnight, there was a good performance against Aberdeen and one for 20 minutes against AC Milan, one for 45 minutes against Lille and then at the weekend. But he’s not seen such inconsistency from his team since going back to the club – and that will worry him.“Mohamed Elyounoussi was excellent against Motherwell, taking his goals really well and that will be one of the most frustrating things for supporters as they can see players who can perform at a really high level but they’re not doing it in every game at this moment in time.” “Defensively, they’re aggressive from the front playing high up the pitch,” he added. “A lot of the goals against Hamilton were caused by pressing.“Successful teams have to do the other side of the game by working hard and forcing their opponents into mistakes, and they’ve been excellent so far this season.”‘Inconsistency a problem for Lennon and Celtic’ Highlights from the Scottish Premiership match between Motherwell and Celtic. 2:21 ‘A reality check for Duffy’ Highlights of the Scottish Premiership match between Rangers and Hamilton. “It’s been a totally different team, as Steven Gerrard has so much confidence in his players. He can look around at the bench and he’s got international players and everyone seems to be playing with a smile on their face.“Even with players like Jermain Defoe not scoring, they’re still having a big impact on the game. Celtic cruised past Motherwell 4-1 at Fir Park to ease the pressure on under-fire manager Neil Lennon who was delighted with win. Meanwhile, Celtic defender Shane Duffy – a summer signing on loan from Brighton – found himself on the bench for Celtic’s win at Motherwell, and Boyd insists being out of the team will be a reality check for the Republic of Ireland defender.“Shane Duffy has been struggling,” Boyd added.“A lot of people down south have said that Scottish football is easy and have criticised it for a number of years, but a lot of players have experienced difficulties in the past and Duffy is on that list right now.“He has been struggling but because of the way Celtic play on the front foot, it’s natural to drop five or 10 yards as a defender and he’s been a bit isolated.“There’s definitely a defender in there with the number of years he’s played in the Premier League. Being out of the team on Sunday will be a reality check and it’s up to him to force his way back into the team as Celtic have paid big wages for him.” – Advertisement –last_img read more

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Kim Kardashian Smirks in Vacation Photo After Larsa Pippen Interview

first_imgA smirk says it all! Kim Kardashian seemed unfazed after her once-close friend Larsa Pippen detailed their falling out for the first time.The Keeping Up With the Kardashians star, 40, shared four photos via Instagram on Monday, November 9, of herself smiling during a tropical vacation. “Smiles for Miles,” she captioned the post.- Advertisement – In the snaps, Kardashian wore a black bikini top with matching shorts as she posed on a beach and climbed a tree limb near the ocean.The E! personality uploaded the pictures just hours after Pippen, 46, blamed their rift on Kardashian’s husband, Kanye West, during a bombshell appearance on the “Hollywood Raw” podcast.“If Kanye feels like him and Kim are better without me, then let them be without me. I’m OK with that,” she said on Monday’s episode. “I will survive. I want everyone to be happy!”- Advertisement – – Advertisement – The Real Housewives of Miami alum went on to claim that the “Gold Digger” rapper, 43, has “brainwashed” his wife and her famous sisters since the couple married in May 2014.“They all started to ride his wave. If you’re that easily swayed, like the wind, then do I really give a f–k? Should I give a f–k? I don’t know,” she said. “Was I hurt by it? Yes. But at the same time, I’m like, I’ve done nothing. I’ve never done one thing. I’ve been the most honest and truthful best friend to all of them.”- Advertisement – Fans noticed in July that Kardashian and Pippen unfollowed each other on Instagram, sparking rumors that the pair were no longer on good terms. At the time, a source exclusively told Us Weekly that the reality stars “just naturally grew apart over a period of time” and that the KKW Beauty founder simply “wanted to reset [her feed] just to her family and childhood friends.”Pippen, however, insinuated on “Hollywood Raw” that West was behind Kardashian’s decision to unfollow her, saying, “We’re like sisters, we’re family, but if you have to unfollow me to make your home a better place, do it. He talks so much about me being this and that and this and that. I just feel like Kanye was in a place where he really didn’t trust anyone with Kim.”The former Bravo personality also alleged on the podcast that she dated Tristan Thompson before his relationship with Khloé Kardashian and that Travis Scott once called on-off girlfriend Kylie Jenner to claim that Pippen had been “hitting on him” at a nightclub. “That never freaking happened,” she insisted.Kim has yet to directly address Pippen’s claims. Scroll down to see more of her smirky vacation photos!last_img read more

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How Asian film is making moves to take over from Hollywood

first_img“Lots of issues are coming together in a perfect storm in 2020,” explains Mike Goodridge, artistic director of Macao’s International Film Festival and Awards, which holds its fifth edition in December.- Advertisement – – Advertisement –last_img

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GRAY ALTER EGO Titanium iPhone 12 Pro Case uses a flame-torched Aurora coating » Gadget Flow

first_img– Advertisement – The GRAY ALTER EGO Titanium iPhone 12 Pro Case is limited to 500 pieces worldwide as it uses a flame-torched Aurora coating for a handcrafted, unique design. This process means that the titanium changes color under heat for a striking finish. This case creates a bold statement that utilizes defined lines and an unforgettable design to enhance your phone. In fact, you can see all of the details up close on the mechanically textured surface. And in a range of colors, you can mix and match shades to suit your style. Furthermore, using aluminum and titanium ensures that the case remains durable. It’ll also protect your phone from scratches and damages caused by accidental drops. Overall, it’s compatible with iPhone 12, Pro, and Pro Max.last_img

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WHO says SARS outbreak is contained, but cause still unclear

first_img The agency commended Chinese authorities “for taking swift action to contain the latest outbreak once it was recognized and reported, by way of extensive contact tracing and the quarantine and medical observation of such individuals. Once again, it has been demonstrated that SARS is a containable disease.” Because more than 3 weeks have passed since the last patient was isolated, the chain of transmission apparently has been broken, the WHO said in a statement today. But WHO and Chinese experts investigating a Beijing virology laboratory where two SARS patients worked have been unable to pinpoint how the outbreak started, the agency said. Hundreds of people were quarantined during the outbreak. A Reuters report today said 28 staff members from the virology institute were still in quarantine. The nine cases in the outbreak included one death, that of Song’s mother. Except for the 31-year-old man who also worked in the lab, all the cases were traced directly or indirectly to Song. A 20-year-old nurse surnamed Li caught the virus from Song, and it subsequently spread from Li to several members of her family and other contacts. All but two surviving patients in the outbreak had been released from hospitals by May 12. However, the agency said investigators “have serious concerns about biosafety procedures at the Institute—including how and where procedures using SARS coronavirus were carried out, and how and where SARS coronavirus samples were stored.” “Preliminary findings in the investigation have yet to identify a single infectious source or single procedural error at the Institute—and it is conceivable that an exact answer may never be determined,” the WHO said today. See also:center_img Apr 25 WHO guidelines for safe handling of SARS specimenshttp://www.who.int/csr/sars/biosafety2003_04_25/en/ May 18, 2004 (CIDRAP News) – The World Health Organization says China’s latest SARS (severe acute respiratory syndrome) outbreak appears to be contained after nine cases, but its precise origin is still a mystery. May 18 WHO statementhttp://www.who.int/csr/don/2004_05_18a/en/ A 26-year-old woman surnamed Song became ill in late March after working in a lab at the National Institute of Virology for 2 weeks, and a 31-year-old man who worked in the lab fell ill in mid-April. Research on the SARS virus was done in the lab, but the two patients never worked with live virus, the WHO has said. The WHO urged all member countries to review the biosafety practices of labs that work with the SARS virus. The agency said many specimens were collected during and after the 2003 SARS outbreaks, and some are stored in labs with “inappropriate” containment measures. The WHO recommends biosafety level 3 as the minimum rating for labs handling the virus.last_img read more

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California bans mercury-containing vaccines for pregnant women, kids

first_imgOct 1, 2004 (CIDRAP News) – Pregnant women and children younger than 3 in California will soon no longer receive vaccines containing more than a trace of mercury, under a law approved this week.Vaccines for those groups will contain no more than a trace of thimerosal (termed thimerosal-free in the industry)—a preservative in some vaccines that contains ethyl mercury. The law takes effect in July 2006, according to news services.Parent-led activist groups attribute increased rates of autism and other neurological disorders in children to mercury, although scientific studies have failed to confirm any clear link.California becomes the second state, after Iowa, to ban the agent in vaccines.In signing the bill, Gov. Arnold Schwarzenegger said, “I believe that an abundance of caution merits the acceleration of the process already under way to remove thimerosal from the last few vaccines that contain it,” according to a Los Angeles Times story.The bill’s author, Assemblywoman Fran Pavley, D-Agoura Hills, said, “Any time we can reduce public exposure to mercury or any other neurotoxin and there is an alternative readily available, we should be promoting the alternative.”Vaccine producers have voluntarily reduced thimerosal levels in vaccines, except for Aventis Pasteur, sole supplier for flu inoculations for children younger than 2, the Times story said. The company was the only vaccine manufacturer to openly oppose the bill. The agent is used to control bacteria and fungi in multiple-dose vials, the usual and most cost-efficient vehicle for distribution of flu vaccine.An Aventis statement expressed disappointment over the law and concern that it might discourage people from getting flu shots for kids. A UPI story from Aug 27, right after the California Senate passed the bill, said Aventis saw the bill “as unnecessarily frightening at a time when the industry is not yet equipped to satisfy demand without using thimerosal.”The American Academy of Pediatrics and the US Public Health Service joined in calling for removal of the mercury-containing preservative thimerosal from vaccines about 5 years ago. By 2001, all the vaccines recommended at that time for children under age 7 were available without thimerosal or with only trace amounts.But this year, in recommending for the first time that 6- to 23-month-old children routinely get flu shots, the Centers for Disease Control and Prevention (CDC) in May did not go on record in favor of a thimerosal-free formulation of the vaccine.The CDC’s position is that the risk of flu complications far outweighs the risk from thimerosal in the vaccine.See also:May 6, 2004 CIDRAP News story “CDC neutral on thimerosal in flu vaccine for toddlers”http://www.cidrap.umn.edu/cidrap/content/influenza/general/news/may0604thimerosal.htmllast_img read more

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Researchers: Pandemic readiness demands mix of antivirals

first_imgMay 15, 2008 (CIDRAP News) – Certain mutations that make the H5N1 influenza virus resistant to the antiviral drug oseltamivir (Tamiflu) leave it susceptible to zanamivir (Relenza), a finding that suggests nations should not rely on oseltamivir alone in preparing for a flu pandemic, according to a report published by British scientists this week.Writing in the journal Nature, the scientists describe the properties and molecular structures of the neuraminidase proteins from two H5N1 variants that have been found in some humans who were treated with oseltamivir. Their findings show that these mutant forms are resistant to oseltamivir but still susceptible to zanamivir and have structural peculiarities that explain this difference.In combination with other recent findings about oseltamivir-resistant forms of H5N1 and the seasonal flu virus H1N1, “our results indicate that it would be prudent for pandemic stockpiles of oseltamivir to be augmented by additional antiviral drugs, including zanamivir,” says the report by Patrick J. Collins, of the National Institute for Medical Research in London, and colleagues.Oseltamivir makes up 80% to 85% of the US stockpile of antiviral drugs for flu, with zanamivir constituting the rest, according to a recent report by the congressionally chartered Institute of Medicine. The report recommended increasing the stockpile, which contained about 71 million treatment courses as of last month.Neuraminidase, which corresponds to the “N” in virus labels such as H5N1, is a viral surface protein that gives new copies of the virus within infected cells the ability to slip through the cell membrane and find other cells to infect. The British scientists studied the neuraminidase found in wild-type H5N1 viruses and N1 forms of neuraminidase that contained three different mutations:His274Tyr, which has been linked to oseltamivir resistance in some fatal human H5N1 cases and was also found in a number of H1N1 viruses from seasonal flu cases this past winterAsn294Ser, which has been found in more than one subtype of flu virus from patients treated with oseltamivirTyr252His, which has been found in one clade of H5N1 virus and has not been linked with drug treatmentThe researchers analyzed the ability of both antivirals to bind to and inhibit these neuraminidases. They found that, compared with the wild-type neuraminidase, the His274Tyr and Asn294Ser variants showed strong resistance to oseltamivir, while the Tyr252His form was actually more susceptible to the drug. None of the mutant forms showed much increase in resistance to zanamivir.The scientists used x-ray crystallography to examine the structure of the neuraminidases in the hope of finding a physical explanation for the oseltamivir resistance. They detected and diagrammed specific structural characteristics of the oseltamivir-neuraminidase and zanamivir-neuraminidase complexes that appear to account for the differences in resistance.The structural basis for the differences has to do with “an altered hydrophobic pocket in the active site of the enzyme required for oseltamivir binding,” the report says.The researchers note that the His274Tyr mutant was found recently in many oseltamivir-resistant H1N1 viruses isolated from flu patients in Europe, even though the patients had no known exposure to the drug. Like the neuraminidase variants used in the study, the H1N1 isolates remained susceptible to zanamivir.”Evidently, if the His274Tyr mutation also becomes common in avian H5N1, the effectiveness of oseltamivir would be limited and the value of stockpiles compromised,” the scientists write. “Considered together with the success of HAART (highly active antiretroviral therapy) against HIV, it would be prudent to reassess the suitability of single-drug, pre-pandemic stockpiles and to develop effective drug combination treatments.”Bill Hall, a spokesman for the US Department of Health and Human Services (HHS) in Washington, DC, called the Nature report interesting but said it would not prompt a change in the agency’s antiviral stockpiling strategy.”We have known about selected instances of resistance to oseltamivir for some time, but so far, the number of reported instances of such resistance has been extremely limited,” Hall told CIDRAP News by e-mail. “The instances of Tamiflu-resistant viruses are not correlated strongly with intensity of Tamiflu use in a given population or environment. It’s also important to remember that any Tamiflu resistance that may exist in currently circulating viruses is in no way predictive of potential resistance in a yet-to-emerge virus with pandemic potential.”So, this article is interesting from a scientific perspective, but given the limited instances in which resistance has been documented, our public health approach to our stockpiling strategy remains unchanged.”Collins PJ, Haire LF, Lin YP, et al. Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants. Nature 2008 (online publication May 14) [Abstract]http://www.nature.com/nature/journal/vaop/ncurrent/full/nature06956.htmlSee also: Apr 25 CIDRAP News story “IOM: US likely to need bigger antiviral stockpile”Mar 19 CIDRAP News story “Researchers warn of resistant flu, foodborne microbes”Jan 29 CIDRAP News story “Europeans find Tamiflu resistance in seasonal flu virus”last_img read more

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